产品名称

乙酸阿比特龙酯(Abiraterone Acetate)

一般描述

Abiraterone Acetate is an orally active acetate sester form of the steroidal compound abiraterone with antiandrogen activity.

别 称

[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate; CB7630

纯 度

≥98.0%(HPLC)

CAS NO.

154229-18-2

分子式

C²⁶H³³NO²

分子量

391.55

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

Insoluble

乙醇

≥25mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Abiraterone Acetate is an orally active acetate sester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov