产品名称

Dabigatran (BIBR 953)

一般描述

Dabigatran is a potent nonpeptide thrombin inhibitor.

别 称

3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid

纯 度

≥98.0%(HPLC)

CAS NO.

211914-51-1

分子式

C²⁵H²⁵N⁷O³

分子量

471.51

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

Very slightly soluble

乙醇

Very slightly soluble

水

≥30mg/mL

l  生物学信息

生物活性/药理作用

Dabigatran is an aromatic amide obtained by formal condensation of the carboxy group of  2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-beta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an  anticoagulant which is used for the prevention of stroke and systemic embolism. It has a role as an anticoagulant, an EC 3.4.21.5 (thrombin) inhibitor and an EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov