产品名称

Leuprorelin(亮丙瑞林)

一般描述

Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.

别 称

Glp-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

纯 度

≥98% (HPLC)

醋酸含量

≤12.0%

水分

≤5.0%(Karl Fischer)

CAS NO.

53714-56-0

分子式

C⁵⁹H⁸⁴N¹⁶O¹²

分子量

1209.421

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

l  生物学信息

生物活性/药理作用

Leuprolide Acetate is the acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov