产品名称

Desmopressin Acetate

一般描述

Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2  receptor (V2R).

纯 度

≥98.0%(HPLC)

肽含量

≥70.0%

分子式

C⁴⁶H⁶⁴N¹⁴O¹²S · xC²H⁴O² · yH²O

分子量

1069.224(anhydrous free base basis)

CAS NO.

16679-58-6

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色粉末

溶解性(25°C)

DMSO

≥45mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Desmopressin  is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin  binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide  (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through  V1a receptor, thereby promotes blood coagulation.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov