产品名称

Dutasteride(度他雄胺)

一般描述

Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).

别 称

GI198745, GG-745

纯 度

≥98.0%(HPLC)

CAS NO.

164656-23-9

分子式

C²⁷H³⁰F⁶N²O²

分子量

528.539

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25°C)

DMSO

≥50mg/ml

乙醇

≥15mg/ml

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Dutasteride is a synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov