产品名称

Bisoprolol fumarate(富马酸比索洛尔)

一般描述

Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.

别 称

EMD33512; but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol

纯 度

≥99.0%(HPLC)

CAS NO.

104344-23-2

分子式

C²²H³⁵NO⁸

分子量

441.521

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥50mg/ml

乙醇

≥50mg/ml

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Bisoprolol Fumarate is the fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. In addition, this agent may exhibit antihypertensive activity through the inhibition of renin secretion by juxtaglomerular epithelioid (JGE) cells in the kidney, thus inhibiting  activation of the renin-angiotensin system (RAS). Bisoprolol has been shown to be cardioprotective in animal models.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov