Dexrazoxane HCl (ICRF-187, ADR-529)
商品编号:
TS0539
备注:
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详细介绍
l 基本信息 |
产品名称 | Dexrazoxane HCl |
一般描述 | Dexrazoxane HCl is an intracellular iron chelator, which decreases the formation of
superoxide radicals, used as a cardioprotective agent also an inhibitor of topoisomerase II |
别 称 | ICRF-187 (ADR-529) HCl; 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride |
纯 度 | ≥97.0%(HPLC) | CAS NO. | 149003-01-0 |
分子式 | C11H17ClN4O4 | 分子量 | 304.731 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25°C) | DMSO | ≥45mg/ml |
乙醇 | Insoluble |
水 | ≥45mg/ml |
l 生物学信息 |
生物活性/药理作用 | Dexrazoxane Hydrochloride is the
hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |