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详细介绍
l 基本信息 |
产品名称 | Leflunomide(来氟洛米) |
一般描述 | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD, used as an immunosuppressant agent. |
别 称 | HWA486; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 75706-12-6 |
分子式 | C12H9F3N2O2 | 分子量 | 270.211 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至浅黄色固体 |
溶解性(25°C) | DMSO | ≥35mg/ml |
乙醇 | ≥35mg/ml |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Leflunomide is a derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
