产品名称

Dienogest(地诺孕素)

一般描述

Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.

别 称

STS 557

纯 度

≥98.0%(HPLC)

CAS NO.

65928-58-7

分子式

C²⁰H²⁵NO²

分子量

311.425

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色或浅黄色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

Insoluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive. Upon oral administration, dienogest binds intracellular progesterone receptors which then translocate to the nucleus where the drug-receptor complex interacts with progesterone response elements, thus altering the of target genes. Dienogest reduces the production of estradiol, prevents ovulation and alters the cervical mucus and endometrium. In  addition, dienogest appears to suppress the of cell cycle regulator cyclin D1. Altogether, this may prevent the growth of endometrial epithelial cells and may reduce symptoms associated with leiomyoma.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov