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Floxuridine

商品编号: TS0560
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详细介绍

l  基本信息

产品名称

Floxuridine(5--2'-脱氧脲核苷)

一般描述

Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.

别 称

Deoxyfluorouridine, FDUR, NSC 27640; 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

纯 度

≥98.0%(HPLC)

CAS NO.

50-91-9

分子式

C9H11FN2O5

分子量

246.194

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥25mg/ml

乙醇

~5mg/ml

≥25mg/ml

l  生物学信息

生物活性/药理作用

Floxuridine is a fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov