产品名称

Ivermectin(伊维菌素)

一般描述

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

别 称

MK933

纯 度

Ivermectin B1A: ≥90.0%(HPLC)

Ivermectin B1B: ≤5.0%(HPLC)

Ivermectin B1A+ Ivermectin B1B: ≥95.0%(HPLC)

CAS NO.

70288-86-7

分子式

C⁴⁸H⁷⁴O¹⁴

分子量

875.106

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色或米黄色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

≥5mg/ml

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Ivermectin is a macrocyclic lactone derived from Streptomyces avermitilis with antiparasitic activity. Ivermectin exerts its anthelmintic effect via activating glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells. Distinct from the channel opening induced by endogenous glutamate transmitter, ivermectin-activated channels open very slowly but essentially irreversibly. As a result, neurons or muscle cells remain at either hyperpolarisation or depolarization state, thereby resulting in paralysis and death of the parasites. Ivermectin does not readily pass the mammal blood-brain barrier to the central nervous system where glutamate-gated chloride channels locate, hence the hosts are relatively resistant to the effects of  this agent.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov