产品名称

Pyridostigmine Bromide(溴吡斯的明)

一般描述

Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

别 称

(1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate; bromide

纯 度

≥98.0%(HPLC)

CAS NO.

101-26-8

分子式

C⁹H¹³BrN²O²

分子量

261.119

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

≥45mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Pyridostigmine Bromide is the bromide salt form of pyridostigmine, a quaternary ammonium carbamate derivative and a acetylcholinesterase inhibitor. Pyridostigmine bromide binds reversibly to acetylcholinesterase active sites in the peripheral nervous system, thereby preventing the breakdown of acetylcholine. This leads to an accumulation of acetylcholine at cholinergic synapses and facilitates transmission of impulses across the neuromuscular junction. Mediated through muscarinic receptors, this agent increases contraction of bronchial and intestinal smooth muscle and the exocrine glands secretions, while it causes paralysis of the skeletal muscles mediated through nicotinic receptors. In addition, pyridostigmine is used as a reversible blocking agent to prevent organophosphates from binding to the acetylcholinesterase receptors and thereby protect the nervous system from the effects of nerve agents such as Soman.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov