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详细介绍
l 基本信息 |
产品名称 | Telbivudine(替比夫定) |
一般描述 | Telbivudine is a potent, and selective HBV reverse tranase inhibitor, used to treat HBV infection. |
别 称 | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 3424-98-4 |
分子式 | C10H14N2O5 | 分子量 | 242.231 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25°C) | DMSO | ≥25mg/ml |
乙醇 | Very slightly soluble |
水 | ≥25mg/ml |
l 生物学信息 |
生物活性/药理作用 | Telbivudine is a synthetic thymidine nucleoside analogue with antiviral activity highly specific for the treatment of hepatitis B virus (HBV). Intracellularly, telbivudine is phosphorylated to its active metabolite, telbivudine triphosphate. The dideoxy telbivudine triphosphate competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse tranase). This results in the blockade of HBV DNA replication and viral propagation. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
