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详细介绍
l 基本信息 |
产品名称 | Dofetilide(多非利特) |
一般描述 | Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug. |
别 称 | UK-68798; N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 115256-11-6 |
分子式 | C19H27N3O5S2 | 分子量 | 441.561 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25°C) | DMSO | ≥45mg/ml |
乙醇 | Insoluble |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
