产品名称

Aminophylline(氨茶碱)

一般描述

Aminophylline is a competitive nive phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nive adenosine receptor antagonist.

别 称

Phyllocontin; 1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine

纯 度

≥98.0%(HPLC)

CAS NO.

317-34-0

分子式

C¹⁶H²⁴N¹⁰O⁴

分子量

420.434

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或微黄色固体

溶解性(25°C)

DMSO

≥35mg/ml

乙醇

Very slightly soluble

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Aminophylline is a methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov