Ipratropium Bromide
商品编号:
TS0691
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详细介绍
l 基本信息 |
产品名称 | Ipratropium Bromide(异丙托溴铵) |
一般描述 | Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD). |
别 称 | [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; bromide |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 22254-24-6 |
分子式 | C20H30BrNO3 | 分子量 | 412.368 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25°C) | DMSO | ≥45mg/ml |
乙醇 | ≥45mg/ml |
水 | ≥45mg/ml |
l 生物学信息 |
生物活性/药理作用 | Ipratropium Bromide is the bromide salt form of ipratropium, a synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic, postganglionic, effector-cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |