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详细介绍
l 基本信息 |
产品名称 | Busulfan(白消安) |
一般描述 | Busulfan is a cell cycle non-specific alkylating antineoplastic agent. |
别 称 | 4-methylsulfonyloxybutyl methanesulfonate |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 55-98-1 |
分子式 | C6H14O6S2 | 分子量 | 246.292 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25°C) | DMSO | ≥25mg/ml |
乙醇 | Insoluble |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA tranion. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |