Progesterone
商品编号:
TS0697
备注:
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详细介绍
l 基本信息 |
产品名称 | Progesterone(孕酮) |
一般描述 | Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM An agonist of the membrane progesterone receptors(mPRs) An antagonist of the σ1 receptor. |
别 称 | 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 57-83-0 |
分子式 | C21H30O2 | 分子量 | 348.421 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25°C) | DMSO | ≥5mg/ml |
乙醇 | ≥45mg/ml |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Therapeutic Progesterone is a synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and tranion activation through direct or indirect interaction with tranion factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |