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详细介绍
l 基本信息 |
产品名称 | Nimodipine(尼莫地平) |
一般描述 | Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure. |
别 称 | BAY E 9736; 3-O-(2-methoxyethyl)
5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 66085-59-4 |
分子式 | C21H26N2O7 | 分子量 | 418.446 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 类白色至浅黄色或黄色固体 |
溶解性(25°C) | DMSO | ≥45mg/ml |
乙醇 | ≥45mg/ml |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |