产品名称

Thiotepa

一般描述

Thiotepa(Thioplex) is an alkylating agent used to treat cancer.

别 称

Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide; tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane

纯 度

≥97.0%(HPLC)

CAS NO.

52-24-4

分子式

C⁶H¹²N³PS

分子量

189.217

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

≥45mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Thiotepa is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crossing of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov