产品名称

Nedaplatin(奈达铂)

一般描述

Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.

别 称

azanide; 2-hydroxyacetic acid; platinum(2+)

纯 度

≥98.0%(HPLC)

CAS NO.

95734-82-0

分子式

C²H⁸N²O³Pt

分子量

303.181

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色或黄绿色或绿色固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

Slightly soluble

l  生物学信息

生物活性/药理作用

Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-s, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov