产品名称

Protionamide(丙硫异烟胺)

一般描述

Protionamide is a drug used in the treatment of tuberculosis.

别 称

Prothionamide; 1321-TH; 2-propylpyridine-4-carbothioamide

纯 度

≥98.0%(HPLC)

CAS NO.

14222-60-7

分子式

C⁹H¹²N²S

分子量

180.269

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色固体

溶解性(25°C)

DMSO

≥15mg/ml

乙醇

Slightly soluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Protionamide is a thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov