产品名称

Primidone(扑米酮)

一般描述

Primidone is an anticonvulsant of the pyrimidinedione class.

别 称

NCI-C56360; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione

纯 度

≥98.0%(HPLC)

CAS NO.

125-33-7

分子式

C¹²H¹⁴N²O²

分子量

218.256

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25°C)

DMSO

≥25mg/ml

乙醇

Very slightly soluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Primidone is an analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov