产品名称

Fluticasone propionate(氟替卡松丙酸酯)

一般描述

Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.

别 称

CCI-187881

纯 度

≥97.0%(HPLC)

CAS NO.

80474-14-2

分子式

C²⁵H³¹F³O⁵S

分子量

500.573

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色粉末

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

~5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Fluticasone Propionate is the propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated tranion. Finally, tranional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the tranion of cyclooxygenase 2, which is essential for prostaglandin production.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov