产品名称

D-Cycloserine(D-环丝氨酸)

一般描述

D-cycloserine is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.

别 称

RO-1-9213; (4R)-4-amino-1,2-oxazolidin-3-one

纯 度

≥98.0%(HPLC)

CAS NO.

68-41-7

分子式

C³H⁶N²O²

分子量

102.093

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅奶黄色或淡黄色固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥15mg/mL

l  生物学信息

生物活性/药理作用

Cycloserine is an analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov