产品名称

Ketotifen Fumarate(富马酸酮替芬)

一般描述

Ketotifen Fumarate is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.

别 称

(E)-but-2-enedioic acid;2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one

纯 度

≥98.0%(HPLC)

CAS NO.

34580-14-8

分子式

C²³H²³NO⁵S

分子量

425.499

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色粉末

溶解性(25°C)

DMSO

~5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Ketotifen Fumarate is the fumarate salt of ketotifen, a cycloheptathiophene derivative with anti-allergic activity. Ketotifen selectively blocks histamine (H1) receptors and prevents the typical symptoms caused by histamine release. This agent also interferes with the release of inflammatory mediators from mast cells involved in hypersensitivity reactions, thereby decreasing chemotaxis and activation of eosinophils.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov