产品名称

Memantine HCl(盐酸美金刚)

一般描述

Memantine HCl is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

别 称

3,5-dimethyladamantan-1-amine;hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

41100-52-1

分子式

C¹²H²²ClN

分子量

215.765

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色粉末

溶解性(25°C)

DMSO

≥35mg/mL

乙醇

≥35mg/mL

水

≥25mg/mL

l  生物学信息

生物活性/药理作用

Memantine Hydrochloride is the hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive  N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov