产品名称

Caffeic Acid(咖啡酸)

一般描述

Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound.

别 称

(E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

纯 度

≥98.0%(HPLC)

CAS NO.

331-39-5

分子式

C⁹H⁸O⁴

分子量

180.159

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至奶油色至黄色至浅棕色固体

溶解性(25°C)

DMSO

≥25mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities. Upon administration, caffeic acid acts as an antioxidant and prevents oxidative stress, thereby preventing DNA damage induced by free radicals. Caffeic acid targets and inhibits the histone demethylase (HDM) oncoprotein gene amplified in squamous cell carcinoma 1 (GASC1; JMJD2C; KDM4C) and inhibits cancer cell proliferation. GASC1, a member of the KDM4 subgroup of Jumonji (Jmj) domain-containing proteins, demethylates trimethylated lysine 9 and lysine 36 on histone H3 (H3K9 and H3K36), and plays a key role in tumor cell development.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov