产品名称

Nalidixic acid(萘啶酸)

一般描述

Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.

别 称

NSC-82174; 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

纯 度

≥98.0%(HPLC)

CAS NO.

389-08-2

分子式

C¹²H¹²N²O³

分子量

232.239

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色固体

溶解性(25°C)

DMSO

~5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Nalidixic Acid is a synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder and exerts its local antibacterial actions by interference of DNA gyrase activity, thereby inhibiting DNA synthesis during bacterial replication in a dose-dependent manner. Nalidixic acid is active against most gram-negative organisms that cause urinary tract infections.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov