产品名称

Equol(雌马酚)

一般描述

Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ.

别 称

(3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol

纯 度

≥98.0%(HPLC)

CAS NO.

531-95-3

分子式

C¹⁵H¹⁴O³

分子量

242.274

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米白色固体

溶解性(25°C)

DMSO

≥35mg/mL

乙醇

≥35mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the  of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov