产品名称

Amantadine HCl(1-金刚烷胺盐酸盐)

一般描述

Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.

别 称

1-adamantanamine HCl; adamantan-1-amine; hydrochloride

纯 度

≥97.0%(HPLC)

CAS NO.

665-66-7

分子式

C¹⁰H¹⁸ClN

分子量

187.711

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥25mg/mL

乙醇

≥25mg/mL

水

≥25mg/mL

l  生物学信息

生物活性/药理作用

Amantadine Hydrochloride is the hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov