产品名称

Ciclopirox(环吡酮胺)

一般描述

Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator.

别 称

6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one

纯 度

≥98.0%(HPLC)

CAS NO.

29342-05-0

分子式

C¹²H¹⁷NO²

分子量

207.273

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥35mg/mL

乙醇

≥35mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe₃₊ and Al₃₊, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that  are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov