产品名称

Nocodazole(诺考达唑)

一般描述

Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.

别 称

Oncodazole; methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

纯 度

≥98.0%(HPLC)

CAS NO.

31430-18-9

分子式

C¹⁴H¹¹N³O³S

分子量

301.32

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米白色和浅粉红色固体

溶解性(25°C)

DMSO

~5mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Nocodazole is a synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov