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详细介绍
l 基本信息 |
产品名称 | CPI-613 |
一般描述 | CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. |
别 称 | 6,8-bis(benzylsulfanyl)octanoic acid |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 95809-78-2 |
分子式 | C22H28O2S2 | 分子量 | 388.584 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至米白色固体 |
溶解性(25°C) | DMSO | ≥50mg/mL |
乙醇 | ≥50mg/mL |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | 6,8-Bis(benzylthio)octanoic Acid is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action is unknown, 6,8-Bis(benzylthio)octanoic acid has been shown to inhibit metabolic and regulatory processes required for cell growth in solid tumors. Both enantiomers in the racemic mixture exhibit antineoplastic activity. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
