产品名称

Zanamivir(扎那米韦)

一般描述

Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.

别 称

(2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; GG167

纯 度

≥98.0%(HPLC)

CAS NO.

139110-80-8

分子式

C¹²H²⁰N⁴O⁷

分子量

332.313

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米白色固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

Insoluble

水

≥25mg/mL

l  生物学信息

生物活性/药理作用

Zanamivir is a sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov