产品名称

Foscarnet Sodium(膦甲酸钠)

一般描述

Foscarnet Sodium inhibits viral RNA polymerases, reverse tranase, and DNA polymerases through noncompetitive inhibition with dNTPs.

别 称

Phosphonoformate; trisodium; phosphonatoformate

纯 度

≥98.0%(HPLC)

CAS NO.

63585-09-1

分子式

CNa³O⁵P

分子量

191.949

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

~5mg/mL

乙醇

Insoluble

水

Slightly soluble

l  生物学信息

生物活性/药理作用

Foscarnet Sodium is the trisodium salt of a synthetic organic analogue of inorganic pyrophosphate with antiviral activity. Foscarnet selectively blocks the pyrophosphate binding site of herpesvirus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. This agent does not require phosphorylation by thymidine kinase (TK) or other kinases and therefore is active in vitro against herpes simplex virus (HSV) TK deficient mutants and cytomegalovirus (CMV) UL97 mutants. Because foscarnet crosses the blood brain barrier, it may be used in the treatment of viral infections of the CNS.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov