产品名称

Etravirine

一般描述

Etravirine is a non-nucleoside reverse tranase inhibitor (NNRTI) used for the treatment of HIV.

别 称

TMC125; R-165335; 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile

纯 度

≥97.0%(HPLC)

CAS NO.

269055-15-4

分子式

C²⁰H¹⁵BrN⁶O

分子量

435.285

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Etravirine is a diarylpyrimidine non-nucleoside reverse tranase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse tranase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov