产品名称

Tripelennamine HCl(盐酸曲吡那敏)

一般描述

Tripelennamine is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.

别 称

Pyribenzamine HCl; N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

154-69-8

分子式

C¹⁶H²²ClN³

分子量

291.823

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

Slightly soluble

乙醇

Slightly soluble

水

≥45mg/mL

l  生物学信息

生物活性/药理作用

Tripelennamine Hydrochloride is the hydrochloride salt form of tripelennamine, an ethylenediamine derivative with an antihistaminergic property. Tripelennamine hydrochloride competitively blocks central and peripheral histamine H1 receptors, thereby limiting histamine's effects, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic activity.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov