产品名称

Ibandronate sodium(伊班膦酸钠)

一般描述

Ibandronate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

别 称

BM-21.0955; sodium; hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate; hydrate

纯 度

≥98.0%(HPLC)

CAS NO.

138926-19-9

分子式

C⁹H²⁵NNaO⁸P²

分子量

359.227

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

Insolube

乙醇

Insolube

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Ibandronate Sodium is the sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov