产品名称

Trifluoperazine 2HCl(三氟拉嗪二盐酸盐)

一般描述

Trifluoperazine 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

别 称

SKF5019; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine; dihydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

440-17-5

分子式

C²¹H²⁶Cl²F³N³S

分子量

480.415

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Trifluoperazine Hydrochloride is the hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov