产品名称

Ilaprazole(艾普拉唑)

一般描述

Ilaprazole is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H₊/K₊-ATPase with an IC50 of 6.0 μM.

别 称

IY-81149; 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1H-benzimidazole

纯 度

≥98.0%(HPLC)

CAS NO.

172152-36-2

分子式

C¹⁹H¹⁸N⁴O²S

分子量

366.439

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米白色固体

溶解性(25°C)

DMSO

≥50mg/mL

乙醇

≥5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Ilaprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H₊/K₊ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H₊ ions into the gastric lumen, the final step in gastric acid production.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov