产品名称

2,4-Diamino-6-hydroxypyrimidine(2,4-二氨基-6-羟基嘧啶)

一般描述

2,4-Diamino-6-hydroxypyrimidine is a specific inhibitor for GTP cyclohydrolase I, the rate-limiting enzyme in de novo pterin synthesis.

别 称

DAHP; 2,4-diamino-1H-pyrimidin-6-one

纯 度

≥98.0%(HPLC)

CAS NO.

56-06-4

分子式

C⁴H⁶N⁴O

分子量

126.119

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥15mg/mL

乙醇

Insoluble

水

~5mg/mL

l  生物学信息

生物活性/药理作用

2, 4-Diamino-6-hydroxypyrimidine (DAHP) is a selective inhibitor of GTP cyclohydrolase I (GTPCH) that restricts the de novo synthesis of tetrahydrobiopterin (BH4) or the BH4 precursor in vascular smooth muscle cells (VSMC). (PMID: 12883322). 2, 4-Diamino-6-hydroxypyrimidine also inhibits nitric oxide (NO) in both Interferon-gamma (IFN-gamma) and antigen (Ag)/IgE (Ag/IgE) systems, increasing Mast cells (MC) degranulation.(PMID: 14514683). Sepiapterin, a precursor to tetrahydrobiopterin in the salvage pathway, completely reverses the effect of 2, 4-diamino-6-hydroxypyrimidine on neuronal NO-synthase (nNOS) ubiquitylation.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov