产品名称

Pterostilbene(紫檀芪)

一般描述

Pterostilbene is extracted from Pterocarpus indicus.

别 称

4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol

纯 度

≥99.0%(HPLC)

CAS NO.

537-42-8

分子式

C¹⁶H¹⁶O³

分子量

256.301

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥45mg/mL

乙醇

≥45mg/mL

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

A naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Upon administration, pterostilbene exerts its anti-oxidant activity by scavenging reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced cell damage. It may also activate the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway and increase the  of various antioxidant enzymes, such as superoxide dismutase (SOD). In addition, pterostilbene is able to inhibit inflammation by reducing the  of various inflammatory mediators, such as interleukin (IL) 1beta, tumor necrosis factor alpha (TNF-a), inducible nitric oxide synthase (iNOS), cyclooxygenases (COX), and nuclear factor kappa B (NF-kB). It also inhibits or prevents the  activation of many signaling pathways involved in carcinogenesis, and increases  of various tumor suppressor genes while decreasing  of certain tumor promoting genes. It also directly induces apoptosis in tumor cells.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov