产品名称

Pemirolast potassium

一般描述

Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

别 称

BMY26517; potassium; 9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one

纯 度

≥98.0%(HPLC)

CAS NO.

100299-08-9

分子式

C¹⁰H⁷KN⁶O

分子量

266.305

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色至黄绿色固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥45mg/mL

l  生物学信息

生物活性/药理作用

Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov