产品名称

Terbutaline Sulfate(硫酸特布他林)

一般描述

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

别 称

5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol; sulfuric acid

纯 度

≥99.0%(HPLC)

CAS NO.

23031-32-5

分子式

C²⁴H⁴⁰N²O¹⁰S

分子量

548.648

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Terbutaline Sulfate is the sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating and tocolytic properties. Terbutaline sulfate selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic cAMP production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids the relaxation of airway muscles. Terbutaline sulfate also increases mucociliary clearance and reduces release of inflammatory cell mediators.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov