产品名称

Ceftriaxone Sodium Trihydrate(头孢曲松钠三水合物)

一般描述

Ceftriaxone sodium trihydrate is a third-generation cephalosporin antibiotic.

纯 度

≥98.0%(HPLC)

CAS NO.

104376-79-6

分子式

C¹⁸H¹⁶N⁸Na²O⁷RS³

分子量

661.6

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25°C)

DMSO

Slightly soluble

乙醇

Insolube

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-age of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone  also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov