产品名称

Penciclovir(喷昔洛韦)

一般描述

Penciclovir is a purine acyclic nucleoside analogue with potent antiviral activity.

别 称

BRL-39123, VSA 671; 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one

纯 度

≥99.0%(HPLC)

CAS NO.

39809-25-1

分子式

C¹⁰H¹⁵N⁵O³

分子量

253.262

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥25mg/ml

乙醇

Insoluble

水

Slightly soluble

l  生物学信息

生物活性/药理作用

Penciclovir is a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine  triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov