产品名称

Azaguanine-8(8-氮鸟嘌呤)

一般描述

Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.

别 称

NSC-749, SF-337, SK 1150; 5-amino-2,6-dihydrotriazolo[4,5-d]pyrimidin-7-one

纯 度

≥99.0%(HPLC)

CAS NO.

134-58-7

分子式

C⁴H⁴N⁶O

分子量

152.117

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥5mg/ml

乙醇

Insoluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

8-Azaguanine is a purine analogue with potential antineoplastic activity. 8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by competing with guanine for incorporation into tRNA catalyzed by the enzyme tRNA-guanine ribosyltransferase (tRNA-guanine  transglycosylase). Altered guanine modification of tRNA has been implicated in cellular differentiation and neoplastic transformation. 8-Azaguanine also inhibits the formation of 43S and 80S initiation complexes, thereby interfering with initiation of translation and inhibiting protein synthesis. This agent inhibits tumor cell growth and stimulates cell differentiation.

应 用

Antimetabolites, Antineoplastic

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov