产品名称

Isosorbide(异山梨醇)

一般描述

Isosorbide is a heterocyclic compound that is derived from glucose, used as a diuretic.

别 称

(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol

纯 度

≥97.0%(HPLC)

CAS NO.

652-67-5

分子式

C₆H₁₀O₄

分子量

146.142

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色至浅棕色固体

溶解性(25°C)

DMSO

≥15mg/ml

乙醇

≥15mg/ml

水

≥15mg/ml

l  生物学信息

生物活性/药理作用

Isosorbide is an organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide(NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca₂₊. In turn, free Ca₊ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.

应 用

Diuretics, Osmotic

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov