产品名称

Amoxapine(阿莫沙平)

一般描述

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.

别 称

CL 67772; 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine

纯 度

≥98.0%(HPLC)

CAS NO.

14028-44-5

分子式

C¹⁷H¹⁶ClN³O

分子量

313.785

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

Slightly soluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.

应 用

1.Antidepressive Agents, Tricyclic

2.Dopamine Antagonists

3.Adrenergic Uptake Inhibitors

4.Neurotransmitter Uptake Inhibitors

5.Serotonin Uptake Inhibitors

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov